Formamid
| Product name | Formamid |
| Molecular formula | CH3NO |
| Molecular weight | 45.04 |
| CAS NO. | 75-12--7 |
| EINECS | 200-842-0 |
| Melting point | 2-3℃ |
| Boiling point | 210℃ |
| Water soluble | Miscible with water |
| Density | 1.134 g/mL@25℃ |
| Appearance | Colorless transparent liquid |
| Flash point | 154.4℃ |
| Application | Used as spinning solvent and organic synthesis intermediate |
| Security description | S 53-45-36/37/39-26-23 |
| Hazard symbol | T |
| Risk description | R 61-41-37/38 |
| Use | Formamide has active reactivity and special solubility, and can be used as an organic synthetic raw material, a paper treating agent, a softener for the fiber industry, a softener for animal glue, and an analytical reagent for determining the amino acid content in rice. In organic synthesis, there are many uses in medicine, and there are many uses in pesticides, dyes, pigments, perfumes, and auxiliaries. Used as an intermediate to synthesize imidazole, pyrimidine, 1,3,5-triazine, caffeine, theophylline, and theobromine. Used as a raw material for dyes, perfumes, pigments, binders, textile auxiliaries, paper treatment agents, etc. Raw materials for the production of formic acid and dimethylformamide. It is also an excellent organic solvent, mainly used in spinning and ion exchange resins of acrylonitrile copolymers, as well as antistatic coating or conductive coating of plastic products. In addition, it is also used to separate chlorosilanes, purify oils, and the like. Formamide can undergo a variety of reactions, in addition to the participation of three hydrogens in the reaction, dehydration, CO removal, introduction of amino groups, introduction of acyl groups and cyclization reactions. Take the ring as an example. Diethyl malonate is cyclized with formamide to give the intermediate 4,6-dihydroxypyrimidine of vitamin B4. Cycling of anthranilic acid with an amide to obtain an antiarrhythmogenic intermediate quinazolin-4. 3-Amino-4-ethoxycarbonylpyrazole is cyclized with formamide to obtain xanthine oxidase inhibitor allopurinol . Ethylenediaminetetraacetic acid is cyclized with formamide to obtain an anticancer drug, ethylimine. The methyl methoxymalonate is cyclized with formamide to give the intermediate 5-amino-4,6-dihydroxypyrimidine disodium of the sulfonamide. |
